Our lab studies how gut microbial communities influence host immunity, metabolism, and disease susceptibility. We integrate culturomics, genomics, metabolomics, immunology, and experimental animal models to uncover fundamental principles governing microbiome-host interactions. Our research spans infectious and immune-mediated diseases, with an emphasis on microbe-microbe and microbe-host signaling, bacteriophage-driven microbiome dynamics, and translational strategies to precisely engineer the gut microbiome for therapeutic benefit.